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What is Ketamine?
Ketamine (brand name: Ketalar) is a dissociative injected anesthetic (blocks sensory perception) that has been available by prescription in the U.S. since the 1970s for human and veterinary uses. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved in 2019 for treatment-resistant depression and is approved for use in depressed patients with acute suicidal ideation or behavior. Ketaset is the brand name of a surgical anesthesia used by veterinarians
Dissociative drugs can lead to distortion of sights, colors, sounds, self, and one’s environment. Ketamine is available in a clear liquid or off-white powder form for intravenous injection or as a nasal spray. Examples of other dissociative drugs include phencyclidine (PCP) and dextromethorphan (DXM).
Why is Ketamine Used Medically?
- Ketamine can provide pain relief and short-term memory loss (for example, amnesia of a medical procedure).
- In surgery, it is used an induction and maintenance agent for sedation and to provide general anesthesia.
- It has also been used for pain control in burn therapy, battlefield injuries, and in children who cannot use other anesthetics due to side effects or allergies.
- Ketamine, through blocking at the N-methyl-D-aspartate (NMDA) site, has rapid action in controlling symptoms of depression and acute suicidal ideation.
- At normal doses, it is often preferred as an anesthetic in patients at risk of bronchospasm and respiratory depression.
- How Quickly Does Ketamine Work?
- An injection yields a quick response, with effects occurring in seconds to minutes.
- “Snorting” leads to effects in roughly 5 to 15 minutes (this is the most common method of abuse).
- Oral consumption requires between 5 and 30 minutes.
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