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What is Ketamine?

Ketamine (brand name: Ketalar) is a dissociative injected anesthetic (blocks sensory perception) that has been available by prescription in the U.S. since the 1970s for human and veterinary uses. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved in 2019 for treatment-resistant depression and is approved for use in depressed patients with acute suicidal ideation or behavior. Ketaset is the brand name of a surgical anesthesia used by veterinarians

Dissociative drugs can lead to distortion of sights, colors, sounds, self, and one’s environment. Ketamine is available in a clear liquid or off-white powder form for intravenous injection or as a nasal spray. Examples of other dissociative drugs include phencyclidine (PCP) and dextromethorphan (DXM).

In the U.S., ketamine is classified as a schedule III drug under the DEA Controlled Substances Act; however, it is not classified as an opioid (narcotic) or barbiturate.

Why is Ketamine Used Medically?

• Ketamine can provide pain relief and short-term memory loss (for example, amnesia of a medical procedure).
• In surgery, it is used an induction and maintenance agent for sedation and to provide general anesthesia.
• It has also been used for pain control in burn therapy, battlefield injuries, and in children who cannot use other anesthetics due to side effects or allergies.
• Ketamine, through blocking at the N-methyl-D-aspartate (NMDA) site, has rapid action in controlling symptoms of depression and acute suicidal ideation.
• At normal doses, it is often preferred as an anesthetic in patients at risk of bronchospasm and respiratory depression.
• How Quickly Does Ketamine Work?
  • An injection yields a quick response, with effects occurring in seconds to minutes.
  • “Snorting” leads to effects in roughly 5 to 15 minutes (this is the most common method of abuse).
  • Oral consumption requires between 5 and 30 minutes.
  The effects of abuse typically last 1 to 2 hours, but the users judgement, senses and coordination may be affected for up to 24 hours or longer. Sensations the user may seek include floating, stimulation and visual effects.High doses may dangerously reduce breathing, lead to muscle spasms or weakness, dizziness, balance difficulty, impaired vision, slurred speech, nausea and vomiting, and severe confusion.Binge use, where the user indulges in the drug in excess amounts in a short period of time has been reported, as well.
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